Table 2 Summary of findings. Serum IFNγ, serum NGAL, serum TNF, and serum CRP, CSF NGAL, CSF TNF, CSF IFNγ, and CSF CRP display several characteristics of candidate biomarkers
Biomarker characteristic | Analyte |
|---|---|
Diurnal stability in most PD and HC individuals (Additional file 1; top) | Serum IFNγ, IL-8, and TNF CSF IL-8 and TNF |
Diurnal stability and different between PD and HC (Additional file 1; bottom, Fig. 2, Additional file 2, Additional file 3, and Table 1) | Serum IFNγ, NGAL, and TNF |
Different relationship between CSF and serum levels across the day in PD and HC (Additional file 4) | Serum and CSF CRP and IL-6 |
CSF and serum levels covary at time 0 in both PD and HC subjects (Additional file 6) | CRP |
Covary with α syn and Aβ peptides across the day, and PD and HC subjects have different diurnal relationships (Additional file 5) | Serum IFNγ and CRP CSF TNF and CRP |
Different relationship with α syn and Aβ peptides between PD and HC at time 0 (Fig. 3 and Additional file 7) | Serum CRP CSF IFNγ, NGAL, and CRP |
Covary with UPDRS or components (Fig. 4 and Additional file 8) | Serum IL-8 CSF IFNγ |
Correctly categorizes ≥ 75% of individuals into appropriate group (PD or HC; Additional file 9) | Serum TNF alone (75% +) Serum TNF with CSF α syn (80% +) |