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Table 5 Transcript expression of selected microglia markers and immune modulators

From: Responses of rat and mouse primary microglia to pro- and anti-inflammatory stimuli: molecular profiles, K+ channels and migration

 

Control

I + T

IL-4

IL-10

Relative RNA counts ± SD

Fold change with respect to Control

Rat

Mouse

Rat

Mouse

Rat

Mouse

Rat

Mouse

Aif

(Iba1)

27,167 ± 3842

1 ± 1

1.61

11.07 ↑↑↑ ***

0.65

1.85

1.06

1.35

Cd68

50,573 ± 302

8341 ± 540

0.55 ↓↓↓

0.63 ↓↓↓

0.66 ↓↓↓ ***

1.24 ↑

1.26 ↑ **

0.95

Cx3cr1

1073 ± 235

2819 ± 676

0.03 ↓↓↓

0.02 ↓↓↓

1.45 ↑↑↑

0.05 ↓↓↓ ***

0.65 ↓↓

0.60 ↓↓

Itgam (CD11b)

6778 ± 1635

2767 ± 531

1.08

0.37 ↓↓↓ ***

0.67 **

1.06

1.54 ↑↑

1.82 ↑↑↑

Nfkbia (IκBα)

5791 ± 2491

1057 ± 240

5.77 ↑↑↑ **

4.73 ↑↑↑

0.57

0.58

0.95

1.08

Nr3c1 (GR)

1540 ± 162

414 ± 37

3.53 ↑↑↑ **

3.02 ↑↑↑

0.90

1.05

1.04

1.42 ↑ *

Ptpn6 (SHP-1)

2593 ± 401

2386 ± 318

1.11

3.90 ↑↑↑ ***

1.1

0.63 **

1.15

1.07

Socs1

20 ± 7

10 ± 7

100.93 ↑↑↑

576.90 ↑↑↑ ***

52.38 ↑↑↑

33.03

0.73

1.64

Socs3

62 ± 35

8 ± 5

10.69

72.22 ↑↑↑ ***

1.07

1.41

9.44

63.51 ↑↑↑ ***

Tlr2

3459 ± 1334

326 ± 104

1.22

1.61

0.28 ↓

0.14 ↓↓

1.37

0.84

Tlr4

720 ± 113

634 ± 46

0.58 ↓

1.67 ↑↑ ***

2.18 ↑↑↑ ***

1.45 ↑

1.49 ↑

1.58 ↑

Tspo

2289 ± 1053

655 ± 140

2.82 ↑↑

11.22 ↑↑↑ ***

1.21

1.32

3.43 ↑↑↑

1.99

  1. Treatments, data presentation and analysis are as in Table 3