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Table 1 Patient demographic and disease characteristics at baseline

From: Safety and in vivo immune assessment of escalating doses of oral laquinimod in patients with RRMS

MS-LAQ-101 Pooled placebo
(n = 28)
Laquinimod 0.9 mg
(n = 12)
Laquinimod 1.2 mg
(n = 12)
Laquinimod 1.5 mg
(n = 12)
Laquinimod 1.8 mg
(n = 11)
Laquinimod 2.1 mg
(n = 13)
Laquinimod 2.4 mg
(n = 12)
Laquinimod 2.7 mg
(n = 12)
All (N = 112)
Age, years
 Mean ± SD 37.3 ± 8.5 38.6 ± 10.3 35.8 ± 9.4 35.2 ± 5.3 35.5 ± 8.4 41.5 ± 9.8 38.3 ± 10.5 44.8 ± 7.5 38.3 ± 9.0
 Range 20.9–53.9 21.4–55.9 18.6–48.4 28.8–44.8 23.2–47.2 23.4–56.0 23.6–54.5 31.3–55.5 18.6–56.0
Gender N (%)
 Female 23 (82.1) 10 (83.3) 6 (50.0) 10 (83.3) 5 (45.5) 7 (53.8) 9 (75.0) 9 (75.0) 79 (70.5)
 Male 5 (17.9) 2 (16.7) 6 (50.0) 2 (16.7) 6 (54.5) 6 (46.2) 3 (25.0) 3 (25.0) 33 (29.5)
Height (cm)
 Mean ± SD 170.3 ± 9.5 174.2 ± 9.8 175.8 ± 8.5 169.6 ± 8.1 177.7 ± 10.5 171.9 ± 7.9 171.4 ± 7.7 173.1 ± 6.8 172.6 ± 8.9
 Range 157.0–196.0 158.0–198.0 164.0–196.0 158.0–180.0 158.0–193.0 158.0–186.5 161.0–186.0 164.0–187.0 157.0–198.0
Weight (kg)
 Mean ± SD 72.9 ± 15.3 74.8 ± 14.5 75.9 ± 17.4 77.7 ± 19.1 81.1 ± 18.6 81.0 ± 13.9 79.9 ± 9.9 77.4 ± 12 76.9 ± 15.2
 Range 53.0–110.0 57.0–99.5 58.0–124.0 52.0–113.0 63.0–123.2 62.0–109.5 62.0–98.0 62.0–97.0 52.0–124.0
BMI (kg/m2)
 Mean ± SD 24.9 ± 3.7 24.8 ± 5.5 24.4 ± 4.3 27.0 ± 6.4 25.7 ± 5.0 27.4 ± 4.2 27.3 ± 3.9 25.8 ± 3.6 25.8 ± 4.5
 Range 20.2–36.6 19.8–39.9 18.9–32.3 18.6–36.5 19.1–35.8 21.1–33.0 22.0–33.9 21.5–33.6 18.6–39.9
EDSS score at screening
 Mean ± SD 2.1 ± 1.1 2.0 ± 1.4 1.6 ± 1.2 2.1 ± 1.3 2.4 ± 1.8 2.5 ± 1.2 2.7 ± 1.0 2.6 ± 1.5
 Range 0.0–5.5 0.5–5.5 0.0–4.0 0.0–5.5 0.0–5.5 1.0–5.0 1.0–4.0 1.0–5.5
Total number of exacerbations in the year prior to screening
 Mean ± SD 0.7 ± 0.6 1.2 ± 0.8 1.1 ± 0.8 0.8 ± 0.7 1.2 ± 1.2 1.0 ± 0.9 1.0 ± 0.6 1.0 ± 0.6 0.9 ± 0.8
 Range 0.0–2.0 0.0–3.0 0.0–3.0 0.0–2.0 0.0–4.0 0.0–3.0 0.0–2.0 0.0–2.0 0.0–4.0
  1. BMI body mass index, EDSS Expanded Disability Status Scale, SD standard deviation