Fig. 1

TMP treatment attenuated CCI-induced neuropathic pain. a Single administration of TMP (10, 30, and 90 mg/kg, i.p.) significantly attenuated CCI-induced mechanical allodynia. b Intrathecal injection of TMP (20 μg/20 μl) attenuated CCI-induced mechanical allodynia. c Consecutive administration of TMP (10, 30, and 90 mg/kg, i.p.) for 5 days significantly attenuated CCI-induced mechanical allodynia. Drug administration is indicated by the arrows (n = 6 each group). Two-way ANOVA revealed a significant difference at *P < 0.05 and **P < 0.01 vs. control; and ^# P < 0.05 and ^## P < 0.01 vs. CCI + saline group (Bonferroni post hoc tests)