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Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Elevated microRNA-129-5p level ameliorates neuroinflammation and blood-spinal cord barrier damage after ischemia-reperfusion by inhibiting HMGB1 and the TLR3-cytokine pathway

Fig. 7

Effects of the miR-129-5p mimic and mimic control on hind-limb motor function and blood-spinal cord barrier (BSCB) integrity after IR. a Hind-limb motor function was assessed at 12-h intervals for 48 h after reperfusion using the Basso Mouse Scale for locomotion with a range from 0 (paraplegia) to 9 (normal). b Assessment of each mouse at 48 h post-surgery in the six groups. Each symbol represents one mouse. The bar represents the median. c Changes in BSCB permeability were measured based on EB extravasation visualized as red fluorescence by microscopy. d Quantification of the EB content of the spinal cord (μg/g tissue). e Quantification of the EB fluorescence intensity (INT/mm2). f Quantification of the spinal water content (%). Data are expressed as the mean ± SD. *P < 0.05 versus the Sham group. # P < 0.05 versus the IR group

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Journal of Neuroinflammation

ISSN: 1742-2094