Skip to main content
Fig. 13 | Journal of Neuroinflammation

Fig. 13

From: Peripheral immune tolerance alleviates the intracranial lipopolysaccharide injection-induced neuroinflammation and protects the dopaminergic neurons from neuroinflammation-related neurotoxicity

Fig. 13

Peripheral immune tolerance pre-treated PD rats were protected from intracranial LPS injection-induced neurodegeneration with improved behavioral impairment. Rats from the control group, the PBS (striatum) group, the PBS (i.p.) + LPS (striatum) group, and the LPS (i.p.) + LPS (striatum) group were administrated a single dose of amphetamine (5 mg/kg) on day 28 post to intracranial injection, and the numbers of ipsilateral turns were recorded with 120 min. The results showed alleviated behavioral impairment caused by peripheral LPS pre-treatment. a The numbers of ipsilateral turns per minutes for 120 min after the amphetamine injection. b The total numbers of ipsilateral turns within 120 min after the amphetamine injection. ***P < 0.001 vs. control group. ###P < 0.001 vs. PBS (i.p.) + LPS (striatum) group. The data are presented as the mean ± SEM (n = 6)

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094