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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress

Fig. 5

DMXBA treatment alleviates chronic restraint stress (CRS)-induced neuronal damage in the CA1 region of hippocampus. a Neuronal damage indicated by Nissl staining in the hippocampus of control (Con) and CRS mice treated with vehicle (Veh), DMXBA, or DMXBA plus α-bungarotoxin (α-BGT); scale bar, 30 μm. b Dendrite segments are revealed by Golgi staining in the CA1 region of hippocampus in the different groups; scale bar, 10 μm. Dendritic spines were counted on a 50-μm segment length in 10 neurons from each section. Con, control group. Data are presented as mean ± SEM. n = 6 per group; *P < 0.05 vs. control group; # P < 0.05 vs. CRS 21d + Veh group; + P < 0.05 vs. CRS 21d + DMXBA group

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