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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity

Fig. 4

AM404 concentration dependently reduces LPS-induced PGD2 (a) and 8-isoprostane (b) release after LPS stimulation in primary rat microglial cells. AM404 was added 30 min before stimulating with LPS, and the amount of PGD2 (a) and 8-iso-PGF (b) in the culture medium were determined after 24 h using an enzyme immunoassay. Each column and error bar represents the mean ± SEM of five new cultures/group. *p < 0.05, **p < 0.01, and ***p < 0.001 with respect to LPS (one-way ANOVA followed by the Newman-Keuls post-test)

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