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Fig. 13 | Journal of Neuroinflammation

Fig. 13

From: Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype

Fig. 13

CRT0066101 abrogates the secretion of pro-inflammatory cytokines and chemokines. PMM were cultured on 24-well plates and serum-starved overnight. The supernatants were collected after incubation with DMSO, DMSO plus LPA (1 μM), or LPA (1 μM) plus CRT (1 μM). ELISAs were used to quantitate IL-6, IL-1β, CXCL10 (IP-10), TNF-α, CXCL2 (MIP-2), and CCL5 (RANTES) concentrations. Results shown represent mean + SD from three independent experiments (N = 3) performed in triplicate (*p < 0.05, **p < 0.01, ***p < 0.001, compared to vehicle control; # p < 0.05, ## p < 0.01, CRT + LPA compared to LPA-treated cells; one-way ANOVA with the Bonferroni correction)

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Journal of Neuroinflammation

ISSN: 1742-2094