Table 1 Intrathecal synthesis, cellular immune response and total protein concentrations in BCS and MS

Number of patients

132

267 [17]

n.a.

Number of samples

146

267 [17]

n.a.

Sex ratio (male to female)

1:1.54

1:1.95 [17]

n.s.

Median age at first lumbar puncture (range)

32 years (4–60)

36 years [17]

n.d.

Relapsing disease course

27/102 (26.5%)

n.d. [17]

n.d.

CSF-restricted OCB, positive, samples

34.1% (29/85)

98.1% (262/267) [17]

< 0.000001

CSF-restricted OCB, positive, patients

35% (28/80)

98.1% (262/267) [17]

< 0.000001

CSF-restricted OCB, transiently positive, patients

50% (1/2)

n.d.

n.a.

Link’s IgG index, elevated, samples

22.6% (7/31)

86.4% (51/59) [20]

< 0.000001

Link’s IgG index, elevated, patients

25% (7/28)

86.4% (51/59) [20]

< 0.000001

CSF WCC, elevated, samples

28.1% (27/96)

58.4% (156/267) [17]

< 0.000001

CSF WCC, median and range, if increased, samples

27/μl (6–371)

< 40/μl in 98% [17]

n.a.

CSF TP, elevated, samples

40.8% (31/76)

n.d.

n.a.

CSF TP, median and range, if increased, samples

75 (46–280)

n.d.

n.a.

ACD, samples

23.6% (17/72)

1.9% (1/54)

< 0.0005