Fig. 4

Reduced macrophage infiltration in CCI mouse ipsilateral DRG and sciatic nerve following WWL70 treatment. The numbers of F4/80 positive macrophages in the DRG (a) and sciatic nerve (b) in mice treated with WWL70 (10 mg/kg) after CCI were remarkably reduced compared to the CCI/vehicle group. (c, d) Quantification of the F4/80-positive cells in DRG and sciatic nerve (mean ± S.E.M., n = 8/group). Scale bar = 50 μm. Merge represents co-localization of DAPI (blue) with F4/80 (green)