Fig. 6
From: Laquinimod ameliorates excitotoxic damage by regulating glutamate re-uptake
Laquinimod beneficial effect on glutamatergic transmission is mediated by GLT-1 function. a–d Bath application of the GLT-1 inhibitor (DHK) in EAE-cerebellar slices incubated with laquinimod blocked the anti-excitotoxic effect of laquinimod on decay time (a) and half width (b) on glutamatergic transmission (for comparison, the dashed line in the graphs indicates control values). c Rise time values were not significantly changed by any of the in vitro treatment. Electrophysiological events on the right are examples of sEPSCs recorded in each EAE condition (vhl, laquinimod and laquinimod plus DHK). Data are expressed as mean ± SEM. One-way ANOVA post hoc comparisons, *p < 0.05, **p < 0.01