Journal of Neuroinflammation

Table 2 Changes in Fcgr expression on DIV 7, 14, and 21 relative to DIV 2

From: Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex

	DIV 7 vs. DIV 2			DIV 14 vs. DIV 2			DIV 21 vs. DIV 2
Gene	R.Exp.	95% CI	p	R.Exp.	95% CI	p	R.Exp.	95% CI	p
Hippocampal cells
FcgrIa	0.084	0.016–0.620	0.002↓	0.021	0.003–0.241	0.000↓	0.036	0.005–1.432	0.002↓
FcgrIIa	0.275	0.088–1.005	0.002↓	0.183	0.022–0.661	0.001↓	0.240	0.048–2.567	0.013↓
FcgrIIb	0.427	0.117–2.224	0.045↓	0.327	0.043–3.014	0.058	0.215	0.036–1.453	0.007↓
FcgrIIIa	0.112	0.011–1.043	0.007↓	0.061	0.011–0.468	0.001↓	0.064	0.011–0.906	0.001↓
Fcgrt	1.209	0.406–3.412	0.512	1.202	0.461–3.745	0.473	1.105	0.320–3.341	0.737
Cortical cells
FcgrIa	0.264	0.046–1.625	0.016↓	0.110	0.007–9.227	0.080	0.051	0.003–9.892	0.074
FcgrIIa	0.392	0.080–1.059	0.005↓	0.262	0.075–0.835	0.001↓	0.093	0.034–0.259	0.002↓
FcgrIIb	0.386	0.106–1.077	0.010↓	0.527	0.037–36.8	0.535	0.308	0.025–5.478	0.185
FcgrIIIa	0.293	0.063–1.359	0.009↓	0.039	0.009–0.147	0.001↓	0.008	0.002–0.024	0.001↓
Fcgrt	2.543	0.532–9.585	0.061	2.135	1.101–4.622	0.002↑	0.991	0.491–2.124	0.967

Relative expression = (concentration of Fcgr gene)/(concentration of reference gene Pgk1) [48]. Wherever the change in expression between two DIVs is statistically significant (p value < 0.05; as determined by built-in randomization techniques in REST 2009 analysis software), arrows represent direction of change in expression (↑ up; ↓ down)
R. Exp. relative expression, CI confidence interval

Back to article page

ISSN: 1742-2094

Contact us

Submission enquiries: journalsubmissions@springernature.com