Skip to main content

Table 2 Changes in Fcgr expression on DIV 7, 14, and 21 relative to DIV 2

From: Fc gamma receptors are expressed in the developing rat brain and activate downstream signaling molecules upon cross-linking with immune complex

  DIV 7 vs. DIV 2 DIV 14 vs. DIV 2 DIV 21 vs. DIV 2
Gene R.Exp. 95% CI p R.Exp. 95% CI p R.Exp. 95% CI p
Hippocampal cells
FcgrIa 0.084 0.016–0.620 0.002↓ 0.021 0.003–0.241 0.000↓ 0.036 0.005–1.432 0.002↓
FcgrIIa 0.275 0.088–1.005 0.002↓ 0.183 0.022–0.661 0.001↓ 0.240 0.048–2.567 0.013↓
FcgrIIb 0.427 0.117–2.224 0.045↓ 0.327 0.043–3.014 0.058 0.215 0.036–1.453 0.007↓
FcgrIIIa 0.112 0.011–1.043 0.007↓ 0.061 0.011–0.468 0.001↓ 0.064 0.011–0.906 0.001↓
Fcgrt 1.209 0.406–3.412 0.512 1.202 0.461–3.745 0.473 1.105 0.320–3.341 0.737
Cortical cells
FcgrIa 0.264 0.046–1.625 0.016↓ 0.110 0.007–9.227 0.080 0.051 0.003–9.892 0.074
FcgrIIa 0.392 0.080–1.059 0.005↓ 0.262 0.075–0.835 0.001↓ 0.093 0.034–0.259 0.002↓
FcgrIIb 0.386 0.106–1.077 0.010↓ 0.527 0.037–36.8 0.535 0.308 0.025–5.478 0.185
FcgrIIIa 0.293 0.063–1.359 0.009↓ 0.039 0.009–0.147 0.001↓ 0.008 0.002–0.024 0.001↓
Fcgrt 2.543 0.532–9.585 0.061 2.135 1.101–4.622 0.002↑ 0.991 0.491–2.124 0.967
  1. Relative expression = (concentration of Fcgr gene)/(concentration of reference gene Pgk1) [48]. Wherever the change in expression between two DIVs is statistically significant (p value < 0.05; as determined by built-in randomization techniques in REST 2009 analysis software), arrows represent direction of change in expression (↑ up; ↓ down)
  2. R. Exp. relative expression, CI confidence interval