Fig. 1

Experimental design. P.gingivalis-LPS (5 mg kg⁻¹, i.p.) was administered in the P.gingivalis-LPS group and P.gingivalis-LPS plus TAK group. Seven days after P.gingivalis-LPS administration, cognitive function was assessed by the open field test (OFT), Morris water maze (MWM) test, and passive avoidance test (PAT). The underlying mechanism was further detected by RT-PCR, ELISA, western blot, and immunohistochemistry