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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: Decreased microglial activation through gut-brain axis by prebiotics, probiotics, or synbiotics effectively restored cognitive function in obese-insulin resistant rats

Fig. 5

Effects of prebiotics, probiotics, or synbiotics on brain microglia morphology. a-h Representative images of Iba-1 immunofluorescent under confocal microscopy at CA1 of the hippocampus (bar = 50 μm). i Soma area of Iba-1 positive cell. j Processes length of Iba-1 positive cell. k The ramification of Iba-1 positive cell. l Number Iba-1 positive cell. m Mean fluorescent intensity of Iba-1 positive cell. ND: 24-week-normal diet-fed rats; HFD: 24-week high fat-fed rats; V: rats receiving PBS as vehicle; PE: rats receiving prebiotics; PO: rats receiving probiotics; C: rats receiving combination of prebiotics and probiotics as synbiotics (3 microglial calls/slice, 3 slices/animal and 6 animals/ group) *p < 0.05 in comparison with the ND-fed rats; †p < 0.05 in comparison with the HFD-fed rats receiving vehicle

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