Fig. 2

Effects of IL-1RA and IL-1RA-PEP on transient MCAO-induced endogenous IgG leakage and permeability of FITC-dextran. a Extravasation of endogenous IgG, and intravenous injection and measurement of FITC-dextran tracer were evaluated in the different groups. Increases (%) in IgG (b) and FITC-dextran (c) were represented by the proportion of the areas of positive regions in the cerebral cortex of the ipsilateral hemisphere. Scale bar, 100 and 200 μm for the inserts. Data are shown as mean ± SEM; **P < 0.01, ***P < 0.001 compared to the vehicle group, #P < 0.05 compared to the IL-1RA group, n = 6 per group, based on one-way ANOVA with Bonferroni correction. MCAO middle cerebral artery occlusion, FITC-dextran fluorescein isothiocyanate–dextran