Fig. 3

STF-083010 ameliorated brain atrophy and improved physical development at 6 weeks post HI. a–c Quantification of right (ipsilateral) to left (contralateral) hemispheric (RH/LH) weight ratio showed that brain atrophy was attenuated after treatment (a), statistical analyses of residual brain volume showed that treatment significantly attenuated HI induced brain tissue loss (b) and top view of the brains and brain slices with Nissl staining at 6 weeks post HI (c). d–f Body weight gain (d), quantification of organ (heart, lung, liver, spleen, and kidney) to body weight ratios showed no significant difference between groups (e) and representative photographs of organs (f). Data are expressed as mean ± SEM, n = 8 in sham or vehicle+HI groups and 9 in STF + HI group. **P < 0.01 compared with sham group, *P < 0.05 compared with sham group, ^##P < 0.01 compared with vehicle+HI group, and ^#P < 0.05 compared with vehicle+HI group