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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Selective killing of spinal cord neural stem cells impairs locomotor recovery in a mouse model of spinal cord injury

Fig. 2

SC-NSC activation and differentiation upon SCI. a Representative confocal images showing the central canal of healthy Nestin floxGFPflox-TK mice labeled for GFP and BrdU. b, c Segments proximal (b) and distal (c) to the lesion epicenter from a Nestin floxGFPflox-TK mouse sampled 14 days after SCI. df Quantifications of GFP+BrdU+ cells (means ± S.E.M) within the ependymal layer of the central canal in Nestin floxGFPflox-TK mice sacrificed 3, 14, and 21 days after SCI (n = 3 mice/time point). gj NestinCreERT2Rosa 26YFP mice were injected with TAM for 5 days and, following a washout of further 5 days, subjected to injury. Confocal images of OLIG2/YFP (arrows indicate double positive cells), GFAP+YFP+, and NeuN+YFP+ are provide in gi. Quantifications (means ± S.E.M.) are plotted on j, (n = 3 for each group). Two-way ANOVA, followed by Bonferroni’s multiple comparison test has been used to analyze data of j. Scale bar 30 μm

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