Fig. 3

SC-NSCs are involved in the spontaneous process of functional recovery form spinal cord injury. Histogram in a, shows locomotor functions of saline control mice (black dots, n = 5), saline Nestin^TK mice (gray dots, n = 5), GCV-WT mice (blued dots, n = 8), and GCV-Nestin^TK mice (red dots, n = 5). Data are represented as Basso Mouse Scale (± S.E.M.) mean values of the locomotor score of each group. b Basso Mouse Scale (± S.E.M.) mean values of the locomotor score of individual mice on day 31 (each dot represent a single animal). Data derived from one representative experiment that has been replicated two times. Statistical analysis in a has been done comparing at each time point GCV-WT and GCV-Nestin^TK mice. Day 10, p = 0.044; day 14, p = 0.026; day 18, p = 0.007; day 21, p = 0.008; day 24, p = 0.0044; day 28, p = 0.0045; day 31, p = 0.0044. Results in b have been assayed by repeated measures ANOVA followed by Bonferroni’s multiple comparison test. **p = 0.0045 for GCV versus Nestin^TK + GCV; p = 0.0015 for Nestin^TK + GCV versus untreated; p = 0.0002 for Nestin^TK + GCV versus Nestin^TK