Table 1 Effect of genetic depletion of prodynorphin on MA-induced changes in activity in enzymatic antioxidants

Saline

1 h

3 h

6 h

12 h

1 day

3 days

Dorsal striatum

WT

6.1 ± 0.6

7.5 ± 0.5^†

8.4 ± 0.7^*’‡

12 ± 0.4^**‡

11.1 ± 0.8^**‡

10.0 ± 0.3^**‡

6.5 ± 0.4

DYN KO

6.0 ± 0.3

–

–

15.5 ± 0.7^**,#

–

12.9 ± 0.3^**,#

–

NAc

WT

5.0 ± 0.3

5.6 ± 0.5

6.7 ± 0.3^*

6.3 ± 0.3^**

7.1 ± 0.6^*

6.8 ± 0.4^*

5.7 ± 0.4

DYN KO

4.8 ± 0.4

–

–

11.1 ± 0.5^**,#

–

9.1 ± 0.5^**,#

–

Ventral midbrain

WT

5.8 ± 0.4

6.5 ± 0.4

7.4 ± 0.3^*,&

9.7 ± 0.6^**,&

8.4  ± 0.5^**,&

7.9 ± 0.4^**,&

6.3 ± 0.5

DYN KO

5.9 ± 0.6

–

–

12 ± 0.6^**,#

–

10.2 + 0.4

–

Saline

1 h

3 h

6 h

12 h

1 day

3 days

Dorsal striatum

WT

1.7 ± 0.09

2.0 ± 0.16^†

2.1 ± 0.07^*,†

2.4 ± 0.14^**,†

2.6 ± 0.19^**,‡

2.5 ± 0.13^**,‡

1.9 ± 0.09

DYN KO

1.6 ± 0.08

–

–

2.4 ± 0.06^**

–

2.2 ± 0.08^*

–

NAc

WT

1.4 ± 0.06^&

1.5 ± 0.1

1.6 ± 0.08^*

1.7 ± 0.08

1.9 ± 0.06^**

1.8 ± 0.11^*

1.6 ± 0.07^*

DYN KO

1.2 ± 0.05

–

–

1.8 ± 0.08^*

–

1.6 ± 0.09^*

–

Ventral midbrain

WT

1.6 ± 0.09

1.7 ± 0.32

1.8 ± 0.12

1.9 ± 0.09^*

2.2 ± 0.13^**,&

2.1 ± 0.11^**,&

1.8 ± 0.09

DYN KO

1.3 ± 0.07

–

–

2 ± 0.09^*

–

1.8 ± 0.09^*

–

Saline

1 h

3 h

6 h

12 h

1 day

3 days

Dorsal striatum

WT

9.9 + 0.3

8.5 ± 0.8

7.4 ± 0.4^*

4.9 ± 0.5^**,†

5.4 ± 0.3^**,†

5.6 ± 0.4^**,†

8.4 ± 0.6

DYN KO

9.3 ± 0.5

–

–

3.9 ± 0.5^**,#

–

5.3 ± 0.4^**,#

–

NAc

WT

8.7 ± 0.4

8.3 ± 0.3

7.3 ± 0.3^*

6.3 ± 0.3^**

6.7 ± 0.2^**

7.1 ± 0.5^**

8.3 ± 0.2

DYN KO

8.2 ± 0.4

–

–

4.9 ± 0.3^**,#

–

6.1 ± 0.4^**,#

–

Ventral midbrain

WT

9.2 ± 0.6

8.7 ± 0.3

7.8 ± 0.5^*

6.7 ± 0.3^**

6.7 ± 0.5^**

7.0 ± 0.4^**

8.6 ± 0.3

DYN KO

8.9 ± 0.4

–

–

5.1 ± 0.5^**,#

–

6.3 ± 0.5^**,#

–