Fig. 2

Effect of neurokinin-1 receptor (NK1R) antagonism on LPS-induced increase in proinflammatory cytokine expression in the hippocampus. Rats were treated with L822429 (30 mg/kg) 1 h prior to LPS (200 μg/kg) and sacrificed 2 h after LPS injection. mRNA transcript levels were measured using qPCR. NK1R antagonism attenuates LPS-induced increase in expression of 1L1-β (a), TNF-α (b), and IL-6 (c). n = 5–6/group. *p < 0.05, ***p < 0.001, compared to the vehicle-saline group. ^##p < 0.01, ^###p < 0.001, compared to the vehicle-LPS group