Fig. 8

Increased macrophage infiltration and chronic microglial activation in the spinal cord of LP-BM5-infected PD-1 KO animals. a Representative dot plot to distinguish infiltrating macrophages from tissue-resident microglia. b Absolute numbers of macrophages in the spinal cord of uninfected (UI) and infected (Inf) WT and PD-1 KO animals. Pooled data present absolute numbers (mean ± SD) of infiltrating macrophages within infected and uninfected WT and PD-1 KO animals at 4 weeks p.i. from two independent experiments using three animals per group. **p < 0.01. c Pooled data present the frequency (mean ± SD) of microglial cells expressing MHCII in spinal cord tissues of uninfected (UI) and infected (Inf) WT as well as PD-1 KO animals at 4 weeks p.i. *p < 0.05, **p < 0.01