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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Lentivirus-mediated overexpression of OTULIN ameliorates microglia activation and neuroinflammation by depressing the activation of the NF-κB signaling pathway in cerebral ischemia/reperfusion rats

Fig. 1

Cerebral ischemia/reperfusion increased the levels of OTULIN mRNA and protein at the indicated time points (6, 12, 24, 48, and 72 h) after reperfusion following 2 h of ischemia. a A coronal brain section (stained with TTC) is labeled with black boxes to show the regions analyzed (asterisk represents ischemic core area; boxes represent the ischemic penumbra proximal to the ischemic core area). b OTULIN mRNA levels in the Sham and tMCAO groups at each time point were detected by qRT-PCR (n = 5). c OTULIN protein levels in the Sham and tMCAO groups at each time point were examined with Western blot. d The histogram presents the quantitative analysis of OTULIN protein levels at the indicated time points in the Sham and tMCAO groups (n = 3). All values are presented as the means ± SEMs; ***P < 0.001, **P < 0.01, and *P < 0.05 versus the Sham group

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Journal of Neuroinflammation

ISSN: 1742-2094