Fig. 4

Prx2-induced neurotoxicity was eliminated by microglial Tlr4 knockout or inhibition of MyD88. a When co-cultured with TLR4-KO microglia, the neurotoxicity caused by Prx2 was eliminated after SAH. b Inhibition of MyD88 in microglia by ST-2825 in 100 μmol/L eliminated the Prx2-induced microglia-mediated neurotoxicity. c Inhibition of NF-κB by PDTC in 80 μmol/L significantly remitted the neuronal cytotoxicity caused by Prx2. ^###P < 0.001 vs control; *P < 0.05, **P < 0.01, ***P < 0.001, and ^nsP > 0.05 vs indicated groups. Bars represent the mean ± SD. N = 6 in each group