Fig. 3

Viperin limits neurovirulence and control virus replication in the olfactory bulb and cerebrum. a–b Survival analysis of 6- to 8-week-old WT and viperin^−/− mice after intracranial inoculation of 10 (a) and 100 (b) FFU of LGTV (n = 10). Survival differences were tested for statistical significance by log-rank test. c–f Viral burdens in the brain regions (olfactory bulb, cerebrum, cerebellum, and brainstem) of WT or viperin^−/− mice infected intracranially with 100 FFU of LGTV (n = 5) were measured by qPCR at the indicated time points after infection. Bars indicated mean values. Asterisks indicate statistical significance calculated by the Mann-Whitney test (*P < 0.05; **P < 0.01)