Skip to main content
Fig. 7 | Journal of Neuroinflammation

Fig. 7

From: Roles of astrocytic connexin-43, hemichannels, and gap junctions in oxygen-glucose deprivation/reperfusion injury induced neuroinflammation and the possible regulatory mechanisms of salvianolic acid B and carbenoxolone

Fig. 7

Effects of ACM and MCM on HT-22 neuronal cell lines subjected to OGD/R injury. Cell apoptosis rates in HT-22 murine hippocampal cells, as measured by flow cytometry with an AnnexinV-FITC/PI Apoptosis Detection Kit. a, b The OGD/R group HT-22 cells exhibited higher apoptosis after reperfusion with OGD/R-ACM than after reperfusion with Normal-ACM (51.78 ± 4.66% vs. 20.81 ± 2.65%, p < 0.01). This increase was reversed in HT-22 cells treated with OGD/R-SalB-ACM (13.86 ± 2.90%, p < 0.001) or OGD/R-CBX-ACM (16.98 ± 3.96%, p < 0.01). c, d MCM had an effect similar to that of ACM. We evaluated the statistical significance with ANOVA and Duncan’s multiple comparisons test. *p < 0.05, **p < 0.01, and ***p < 0.001

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094