Fig. 5
From: Toll-like receptor 3 modulates the behavioral effects of cocaine in mice
Inhibition of TLR3 weakens cocaine-induced CPP and locomotor activity in wide-type mice. a Intra-NAc TLR3/dsRNA complex inhibitor (50 μM, 1 μl/injection) attenuates cocaine CPP (20 mg/kg). **p < 0.01, n = 16/DMSO+CO group, n = 17/inhibitor+CO group, n = 16/DMSO+SA group, n = 16/inhibitor+SA group. b, c Group mean total distance traveled in centimeters in the 15 mins after cocaine administration every day (20 mg/kg/day). DMSO control group showed greater locomotor activity than the inhibitor group over all injection days. ***p < 0.001, n = 13/DMSO+CO group, n = 13/inhibitor+CO group, n = 10/DMSO+SA group, n = 11/inhibitor+SA group. Cocaine (CO), saline (SA). Data are presented as the mean ± SEM