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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Central blockade of NLRP3 reduces blood pressure via regulating inflammation microenvironment and neurohormonal excitation in salt-induced prehypertensive rats

Fig. 1

Effects of NLRP3 on MAP in salt-induced prehypertension rats. a The blood pressure of the high-salt group increased gradually after 2 months of high-salt diet in comparison with control group. b Compared with HS + vehicle rats, chronic PVN infusion of MCC950 a specificity NLRP3 antagonist for 4 weeks attenuated hypertension. Blood pressure continued to arose after 4 weeks of discontinuation treatment. Values are expressed as means ± SEM, n = 6–8. *P < 0.05, NS vs HS, or NS + vehicle vs HS + vehicle, †P < 0.05, HS + MCC950 vs HS + vehicle, #P < 0.05, HS + MCC950’ vs NS + MCC950’

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Journal of Neuroinflammation

ISSN: 1742-2094