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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Inhibition of peripheral macrophages by nicotinic acetylcholine receptor agonists suppresses spinal microglial activation and neuropathic pain in mice with peripheral nerve injury

Fig. 6

Suppressive effects of peripheral nAChR agonists on upregulation of microglial molecules in the SDH after PSL. Mice were subject to PSL or sham surgery. TC-2559 or sazetidine A was administered (p.n., 20 nmol) on days 0, 1, 2, and 3, and the lumbar SDH (L4–5) was collected. Expression levels of Iba1, CD11b, CD68, IRF5, IRF7, IL-1β, and CCL3 mRNA on day 7 after PSL were analyzed by RT-qPCR. Data are presented as the mean ± SEM; n = 6–7. ***P < 0.001, **P < 0.01 versus sham. ##P < 0.01, #P < 0.05 versus PSL/Veh

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Journal of Neuroinflammation

ISSN: 1742-2094