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Fig. 4 | Journal of Neuroinflammation

Fig. 4

From: The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death

Fig. 4

Anti-Aβ protofibril selective antibodies reduce the levels of intracellular Aβ. The Aβ levels in total cell lysates were measured using Aβ1-x and Aβx-42 ELISA. Both Aβ1-x (a) and Aβx-42 (b) levels were reduced in cultures treated with Aβ42 protofibrils + mAb158, Aβ42 protofibrils + RmAb158, or Aβ42 protofibrils + N297D, compared to cultures exposed to Aβ42 protofibrils only. All concentrations are expressed in nanomolar (nM) units. Mean values are from duplicates of three independent experiments, from two repeated analyses (**P < 0.01)

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