Fig. 4

Anti-Aβ protofibril selective antibodies reduce the levels of intracellular Aβ. The Aβ levels in total cell lysates were measured using Aβ_1-x and Aβ_x-42 ELISA. Both Aβ_1-x (a) and Aβ_x-42 (b) levels were reduced in cultures treated with Aβ₄₂ protofibrils + mAb158, Aβ₄₂ protofibrils + RmAb158, or Aβ₄₂ protofibrils + N297D, compared to cultures exposed to Aβ₄₂ protofibrils only. All concentrations are expressed in nanomolar (nM) units. Mean values are from duplicates of three independent experiments, from two repeated analyses (**P < 0.01)