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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Vascular adhesion protein-1 is actively involved in the development of inflammatory lesions in rat models of multiple sclerosis

Fig. 2

Traditional and LJP1586-treated EAE lesions can be observed with clinical 3-T MRI using a rat-dedicated brain coil. (a) Representative T2-weighted and Gd-enhanced T1-weighted coronal in vivo MR images and corresponding quantitative data of fDTH-EAE (n = 4) (b) Representative T2-weighted and Gd-enhanced T1-weighted coronal in vivo MR images and corresponding quantitative data of fMOG-EAE (n = 4). (c) Representative T2-weighted and Gd-enhanced T1-weighted coronal in vivo MR images and corresponding quantitative data of LJP1586-treated fMOG-EAE (n = 4). Red arrows indicate lesion sites. T2-weighted MR images display inflammation in hyper-intense areas and Gd-enhanced T1-weighted images reveal BBB status during the course of the disease. Sham-operated rats (n = 4) were used for comparison. *P < 0.05, **P < 0.01, ***P < 0.001

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Journal of Neuroinflammation

ISSN: 1742-2094