Fig. 8
From: Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury
CPD-4645 rescues BBB integrity via endocannabinoid dependent and independent mechanisms. Blockade of endocannabinoid signaling with rimonabant and AM630 (3 mg/kg) does not reverse the BBB protective effects of MAGL inhibition in the inflammation-driven LPS model (a), whereas blockade of endocannabinoid signaling partially reverses the protective effects of MAGL inhibition (administered 30 min post lesion) in the photothrombotic ischemia-driven model (b) as measured by extravasation of 70 kDa FITC-dextran into the brain parenchyma. Data were plotted with means ± SEM (n = 6–9 mice/group) and analyzed with one-way ANOVA with Bonferroni’s post-hoc test. Significance is shown as *p ≤ 0.05, **p ≤ 0.01