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Table 1 Serum protein levels of cytokines

From: Indomethacin promotes survival of new neurons in the adult murine hippocampus accompanied by anti-inflammatory effects following MPTP-induced dopamine depletion

  

Cytokine

  

IL-1β

IL-6

TNF-α

IL-17a

IFN-γ

IL-10

Short-term treatment

CTR + vehicle

123.7 ± 65.7

9.9 ± 1.8

481.2 ± 93.0

22.0 ± 4.8

26.4 ± 4.7

61.4 ± 11.2

MPTP + vehicle

180.8 ± 36.5

11.7 ± 2.2

500.8 ± 104.2

39.0 ± 17.7

27.3 ± 5.3

68.6 ± 13.3

CTR + indomethacin

255.2 ± 30.2

11.6 ± 2.0

537.2 ± 91.4

27.1 ± 4.4

29.9 ± 5.1

76.4 ± 12.1

MPTP + indomethacin

157.5 ± 76.5

9.1 ± 1.3

442.8 ± 91.5

22.8 ± 2.1

26.2 ± 1.8

70.4 ± 4.3

Long-term treatment

CTR + vehicle

94.0 ± 36.0

8.6 ± 1.1

406.3 ± 53.7

15.5 ± 2.2

23.9 ± 3.0

54.7 ± 7.1

MPTP + vehicle

151.4 ± 29.6

11.5 ± 1.9

569.5 ± 82.3

38.2 ± 6.4**

30.0 ± 3.9

88.6 ± 9.7*

CTR + indomethacin

92.0 ± 35.1

10.7 ± 1.7

466.8 ± 89.9

24.6 ± 4.9

27.0 ± 4.3

60.1 ± 10.2

MPTP + indomethacin

126.9 ± 26.7

9.4 ± 1.3

354.8 ± 73.6

19.3 ± 3.6##

24.8 ± 4.2

52.5 ± 9.9##

  1. Multiplex ELISA was performed to evaluate the levels of pro-inflammatory IL-1β, IL-6, TNF-α, IL-17a, and IFN-γ and anti-inflammatory IL-10 in serum of short-term and long-term groups. Values are expressed as mean ± SEM in pg/ml, n = 7–11/group. A two-way ANOVA with factors neurotoxin, drug, and their interaction was performed
  2. CTR control, MPTP 1-methyl-4-(2′-methylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride
  3. A significant interaction was followed by Bonferroni post hoc test: *p ≤ 0.05, **p ≤ 0.01 compared to CTR + vehicle; ##p ≤ 0.01 compared to MPTP + vehicle
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Journal of Neuroinflammation

ISSN: 1742-2094