Fig. 3
From: Procyanidins attenuate neuropathic pain by suppressing matrix metalloproteinase-9/2
Consecutive administration of PC significantly alleviated CCI-induced neuropathic pain and suppressed CCI-induced activation of MMP-9/2 in vivo. (a) Consecutive administration of PC (90 mg/kg, p.o.) for 7 days significantly attenuated CCI-induced mechanical allodynia (n = 6). Behavior tests were carried out at 30 min after PC treatment. b–d PC (90 mg/kg, p.o.) decreased MMP-9/2′ activity in the spinal cords. The lumbar spines (L1–L6) were collected and analyzed 120 min after the last drug administration. Representative bands and a data summary (n = 4) were shown. Significant difference was revealed following one-way or two-way ANOVA (**P < 0.01 vs. control; #P < 0.05, ##P < 0.01 vs. CCI group; Bonferroni post hoc tests)