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Coro1a
|
Coronin1a
|
|
Cell membrane associated protein that interacts with actin filaments to facilitate cell motility, endocytosis, and phagocytosis. Loss of Coro1a expression or ability to bind to F-actin impairs these processes [53].
|
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ATP6ap1
|
ATPase H+ transporting accessory protein 1
|
|
Component of the H+ transporting vacuolar ATPase present in phagosomes [54]
|
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Fcgr1a
|
Fc fragment of IgG receptor Ia
|
|
Complexes with leukotriene B4 receptor in lipid rafts, enhances macrophage anti-microblial actions [55]
|
|
RT1
|
Proteins of the MHC class I family, involved in antigen presentation.
|
|
Ctss
|
Cathepsin S
|
|
Peptidase present in phagolysosomes where it degrades various target proteins [56]
|
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Cyba
|
Cytochrome b-245 alpha chain
|
|
Ncf1
|
Neutrophil cytosolic factor 1
|
|
Components of the NADPH Oxidase complex, present in phagolysomes.
|
|
Slc11a1
|
Solute carrier family 11 member a1, also referred to as Nramp1
|
|
Transmembrane phagosomal divalent cation transporter [57]
|
|
Mfge8
|
Ligand milk fat globule EGF factor-8
|
|
Ligand for Itgb5 (integrain subunit beta 5) required for activation of several pathways, including MerTK activation and F-actin recruitment, involved in clearance [58]
|
|
Psap
|
Prosaponin
|
|
Precursor of saposins A, B, C, and D, which have roles in lysomal degradation pathways [59]
|
|
Sirpa
|
Signal regulatory protein alpha
|
|
Macrophage receptor for CD47 which is a broad inhibitor of phagocytosis [60, 61]
|
|
Calr
|
Calreticulin
|
|
When present on the cell surface acts as a signal to activate macrophage phagocytosis [62]
|
|
CD300lf
|
Member of the CD300 receptor family
|
|
Roles in activating macrophage engulfment by phosphatidylserine signaling [63]
|
|
Pycard
|
PYD And CARD Domain Containing, also referred to as ASC (Apoptosis-Associated Speck-Like)
|
|
Component of the NLRP3 inflammasome, recently shown to play a role in amyloid deposition. [64]
|
