Table 1 Phagosome-related mRNA enriched in alcohol-treated microglia

Coro1a

Coronin1a

Cell membrane associated protein that interacts with actin filaments to facilitate cell motility, endocytosis, and phagocytosis. Loss of Coro1a expression or ability to bind to F-actin impairs these processes [53].

ATP6ap1

ATPase H+ transporting accessory protein 1

Component of the H+ transporting vacuolar ATPase present in phagosomes [54]

Fcgr1a

Fc fragment of IgG receptor Ia

Complexes with leukotriene B4 receptor in lipid rafts, enhances macrophage anti-microblial actions [55]

RT1

Proteins of the MHC class I family, involved in antigen presentation.

Ctss

Cathepsin S

Peptidase present in phagolysosomes where it degrades various target proteins [56]

Cyba

Cytochrome b-245 alpha chain

Ncf1

Neutrophil cytosolic factor 1

Components of the NADPH Oxidase complex, present in phagolysomes.

Slc11a1

Solute carrier family 11 member a1, also referred to as Nramp1

Transmembrane phagosomal divalent cation transporter [57]

Mfge8

Ligand milk fat globule EGF factor-8

Ligand for Itgb5 (integrain subunit beta 5) required for activation of several pathways, including MerTK activation and F-actin recruitment, involved in clearance [58]

Psap

Prosaponin

Precursor of saposins A, B, C, and D, which have roles in lysomal degradation pathways [59]

Sirpa

Signal regulatory protein alpha

Macrophage receptor for CD47 which is a broad inhibitor of phagocytosis [60, 61]

Calr

Calreticulin

When present on the cell surface acts as a signal to activate macrophage phagocytosis [62]

CD300lf

Member of the CD300 receptor family

Roles in activating macrophage engulfment by phosphatidylserine signaling [63]

Pycard

PYD And CARD Domain Containing, also referred to as ASC (Apoptosis-Associated Speck-Like)

Component of the NLRP3 inflammasome, recently shown to play a role in amyloid deposition. [64]