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Table 1 Phagosome-related mRNA enriched in alcohol-treated microglia

From: Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis

Symbol Name and function
Coro1a Coronin1a
Cell membrane associated protein that interacts with actin filaments to facilitate cell motility, endocytosis, and phagocytosis. Loss of Coro1a expression or ability to bind to F-actin impairs these processes [53].
ATP6ap1 ATPase H+ transporting accessory protein 1
Component of the H+ transporting vacuolar ATPase present in phagosomes [54]
Fcgr1a Fc fragment of IgG receptor Ia
Complexes with leukotriene B4 receptor in lipid rafts, enhances macrophage anti-microblial actions [55]
RT1 Proteins of the MHC class I family, involved in antigen presentation.
Ctss Cathepsin S
Peptidase present in phagolysosomes where it degrades various target proteins [56]
Cyba Cytochrome b-245 alpha chain
Ncf1 Neutrophil cytosolic factor 1
Components of the NADPH Oxidase complex, present in phagolysomes.
Slc11a1 Solute carrier family 11 member a1, also referred to as Nramp1
Transmembrane phagosomal divalent cation transporter [57]
Mfge8 Ligand milk fat globule EGF factor-8
Ligand for Itgb5 (integrain subunit beta 5) required for activation of several pathways, including MerTK activation and F-actin recruitment, involved in clearance [58]
Psap Prosaponin
Precursor of saposins A, B, C, and D, which have roles in lysomal degradation pathways [59]
Sirpa Signal regulatory protein alpha
Macrophage receptor for CD47 which is a broad inhibitor of phagocytosis [60, 61]
Calr Calreticulin
When present on the cell surface acts as a signal to activate macrophage phagocytosis [62]
CD300lf Member of the CD300 receptor family
Roles in activating macrophage engulfment by phosphatidylserine signaling [63]
Pycard PYD And CARD Domain Containing, also referred to as ASC (Apoptosis-Associated Speck-Like)
Component of the NLRP3 inflammasome, recently shown to play a role in amyloid deposition. [64]