Fig. 10

Schematic representation of BF cytotoxic effects in primary microglia and organotypic hippocampal slice cultures (OHSCs). Effects of exposure to BF in primary microglia on the production of reactive oxygen species (ROS), release of oxidative stress markers (lipid peroxidation (MDA), nitric oxide (NO), hydrogen peroxides (H₂O₂) and the inflammatory mediators cyclooxygenase-2 (COX-2), microsomal prostaglandin synthase-1 (mPGES-1), prostaglandin E2 (PGE₂), and tumor necrosis factor-alpha (TNF-alpha)). Effects of BF on the activation of both nuclear erythroid-2 like factor-2 (Nrf-2) and nuclear factor kappaB (NF-kappaB). (B) Effect of BF treatment on organotypic hippocampal slice cultures (OHSCs - Ex-Vivo) in the presence or absence of microglia (MG) in slice cultures