Fig. 6

Effects of SN on the expression of hippocampal NLRP1 inflammasome complexes in PTZ kindled rats. a, d, and g Representative immunoreactive bands and statistical results showing SN alone has no influence on the protein expression of NLRP1, ASC, and caspase-1 in protein level. b, e, and h Representative immunoreactive bands and statistical results showing SN dose-dependently inhibited PTZ-induced increase in the protein expression of NLRP1, ASC, and caspase-1 in protein level. c, f, and i Statistical results showing SN dose-dependently inhibited PTZ-induced increase in the expression of NLRP1, ASC, and caspase-1 at mRNA level. Data are expressed as means ± SEM. n = 6–8, ^##P < 0.01 vs control and *P < 0.05 and **P < 0.01 vs PTZ