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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Chronic constriction injury-induced microRNA-146a-5p alleviates neuropathic pain through suppression of IRAK1/TRAF6 signaling pathway

Fig. 2

Expression and cellular distributions of IRAK1 in rat DRG after CCI. a qPCR showing the time course for IRAK1 level in DRG (n = 4 in each group). One-way ANOVA, *P < 0.05, versus sham. b Western blot analyzes the time course for IRAK1 expression in DRG. Representative bands are shown on the top; data summary is shown on the bottom. One-way ANOVA, *P < 0.05, versus sham. c Immunofluorescence showing cellular distribution of IRAK1 in rat DRGs of sham, CCI 7-day, CCI 14-day, and CCI 21-day group. d Quantification analysis from immunofluorescence staining results of IRAK1 in DRG neurons. Percentage of IRAK1-positive neurons in DRGs of sham, CCI (7 days), CCI (14 days), and CCI (21 days) rats. n = 4 in each group, One-way ANOVA, *P < 0.05, versus sham. e Double immunostaining showing co-expression of IRAK1 (green) with CGRP (red) in rat DRG of CCI 14 day. f Double immunostaining showing co-expression of IRAK1 (green) with IB4 (red) in rat DRG of CCI 14 days. Scale bar 25 μm in c, e, and f

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Journal of Neuroinflammation

ISSN: 1742-2094