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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades

Fig. 3

Effects of MSC on the morphometry of sciatic nerve myelinic fibers from mice with diabetic neuropathy. Morphometric analyses of sciatic nerve from non-diabetic mice (control group), diabetic mice treated with saline (STZ + saline), and diabetic mice treated with MSC (1 × 106; STZ + MSC), performed 12 weeks after neuropathy induction. Graphs show a myelinated fibers number, b mean axon diameter, c fiber diameter, d thickness of myelin sheath, and e G-ratio (ratio axon/nerve fiber diameter). Data are expressed as means ± SEM; n = 3 mice per group. *Statistical significance compared to control group (p < 0.05). #Statistical significance compared to STZ + saline group (p < 0.05). One-way ANOVA followed by Tukey post-test

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