Fig. 6
Effect of MSC on the antioxidant profile in the spinal cord of mice with diabetic neuropathy. Four weeks after the neuropathy induction, mice were treated with MSC (1 × 106; STZ + MSC) or saline (STZ + saline) by endovenous route. Control non-diabetic group received saline instead of streptozotocin. The spinal levels of mRNA were measured by RT-qPCR 8 weeks after treatment. Panels show the spinal levels of catalase mRNA (a), superoxide dismutase mRNA (b), glutathione peroxidase mRNA (c), and Nrf2 mRNA (d). Data are expressed as means ± SEM; n = 6 mice per group. *Statistical significance compared to the remaining groups (p < 0.001). One-way ANOVA followed by Tukey’s multiple comparison test