Fig. 4

Assessment of blood-brain barrier dysfunction. a, c Representative brain images show Evans blue leakage at 6 h (a) and 72 h (c) post-surgery in each group. Scale bar = 1 mm. b, d Quantitative analysis of Evans blue leakage in tMCAO + saline and tMCAO + CORM-3 groups at 6 h (b) and 72 h (d) post-surgery (*p < 0.05, n = 8 per group, data are shown as mean ± SD). e Representative fluorescence of Evans blue extravasation in peri-infarction zone at 72 h post-surgery (n = 6 per group). Scale bar = 50 μm