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Table 1 Summary of cohorts and numbers of animals per group

From: Inflammation and blood-brain barrier breach remote from the primary injury following neurotrauma

  Uninjured Day 1 Day 3 Day 7 Day 14 Day 28
Cohort 1
 - Microglia/macrophages in the optic nerve n = 10*   n = 10 n = 10   n = 10
Cohort 2
 - BBB analyses n = 9–12 EB   n = 9–12 EB n = 9–12 EB n = 9–12 EB n = 9–12 EB
 - Microglia/macrophages in the optic tract n = 9 n = 6 no EB n = 6 n = 5–6 n = 4–5 n = 4
Cohort 3
 - Cytokines n = 8 n = 8 n = 8 n = 8   
  1. Day is the day after partial optic nerve transection injury. * For cohort 1, three groups of uninjured controls collected at days 3, 7, and 28 were compared and found to be not different (p ≤ 0.05); the 3-day controls were used for statistical comparisons. EB denotes intravenous injection of Evans blue for the specified animals. Numbers of animals per group are presented as a range if suitable sections were not available for specific brain regions. BBB analyses encompass assessments of Evans blue, caveolin, and fibrinogen immunoreactivity