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Fig. 1 | Journal of Neuroinflammation

Fig. 1

From: Increased hypothalamic microglial activation after viral-induced pneumococcal lung infection is associated with excess serum amyloid A production

Fig. 1

Co-infection in the lung causes pneumococcal brain infection. Mice were infected intranasally with S. pneumoniae (SP, serotype 19F/strain EF3030, 105 CFU) and/or influenza A virus (IAV, strain HKx31, H3N2, 104 PFU) on day 0 and day 1 respectively. On day 7, mice were culled, yielding four groups consisting of control (SAL), single pathogen infection (SP and IAV), and co-infection (SPIAV). Viral titres were assessed in nasopharynx (a) and lung (b), whilst bacterial titres were measured in in nasopharynx (c), lung (d), blood (e) and spleen (f). Dashed lines denote detection limits. n = 4–6; *p < 0.05, two-tailed Student’s unpaired t tests

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