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Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease

Fig. 3

Silencing of Nlrp3 in the liver by siRNA administration in vivo has no effects on the metabolism of MPTP. a Representative images from hematoxylin and eosin staining in the liver samples. b, c The analysis of MAO-B activity in the liver and the striatum via ELISA (n = 4 animals per condition). Samples were collected after 7 days of last MPTP injection. Data is presented as mean ± SEM, two-way ANOVA. d, f MPP+ levels were determined at the times indicated following the treatment with MPTP in liver, striatum, and serum (n = 8 animals per condition). Samples were collected after 90, 120, and 240 min of MPTP single injection. Data is presented as mean ± SEM, two-way ANOVA

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Journal of Neuroinflammation

ISSN: 1742-2094