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Fig. 5 | Journal of Neuroinflammation

Fig. 5

From: An IFNγ/CXCL2 regulatory pathway determines lesion localization during EAE

Fig. 5

CXCL1 is expressed by CNS resident cells during EAE. a CXCL1 (red) was detected in the choroid plexus epithelium in brainstem sections of IFNγRKO mice at the onset of aEAE (clinical score 1), and in astrocytes in spinal cord sections of WT mice at the onset of cEAE (clinical score 2), via immunofluorescent histology. Sections were co-stained with antibodies specific for CD45 (green) and GFAP (white), and counterstained with DAPI (blue). b Choroid plexus samples were obtained at the onset of cEAE or aEAE, or from naïve IFNγRKO mice. CXCL1 transcript was quantified by qPCR and normalized to GAPDH (n = 4–6/group from two experiments)

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