Table 1 Laboratory characteristics of animals before and after treatment modification
From: Brain 18F-FDG PET of SIV-infected macaques after treatment interruption or initiation
| Â | Interruption | Initiation | ||||||
|---|---|---|---|---|---|---|---|---|
Baseline | Month 1 | Month 3 | Month 6 | Baseline | Month 1 | Month 3 | Month 6 | |
CSF VL | 0 (0) | 272 (409) | 16,741 (29,877) | 327 (462) | 6894 (10,533) | 0 (0) | 212 (473) | 0 (0) |
Log CSF VL | 0 (0) | 1.32 (1.54) | 2.41 (2.29) | 1.41 (1.99) | 2.46 (2.56) | 0 (0) | 0.60 (1.35) | 0 (0) |
Plasma VL | 3 (5) | 79,070 (145,887) | 258,608 (303,812) | 919,845 (1,300,023) | 362,834 (449,170) | 41 (67) | 20 (33) | 8 (8) |
Log plasma VL | 0.27 (0.45) | 4.11 (0.99) | 4.10 (2.11) | 4.52 (2.47) | 4.89 (1.15) | 1.15 (0.79) | 0.79 (0.80) | 0.65 (0.60) |
CD4+ cells | 783 (363) | 576 (295) | 450 (345) | 526 (343) | 235 (85) | 487 (331) | 444 (107) | 648 (135) |
Proliferating CD4+ cells | 42 (22) | 26 (7) | 24 (16) | 15 (13) | 12 (5) | 25 (9) | 29 (16) | 43 (17) |
CD8+ cells | 807 (424) | 726 (385) | 710 (427) | 636 (350) | 424 (256) | 763 (483) | 585 (415) | 664 (258) |
Proliferating CD8+ cells | 29 (19) | 36 (21) | 61 (63) | 38 (7) | 24 (13) | 35 (22) | 28 (14) | 40 (21) |
CD4/CD8 ratio | 0.98 (0.16) | 0.83 (0.20) | 0.67 (0.24) | 0.80 (0.10) | 0.64 (0.20) | 0.70 (0.21) | 0.93 (0.38) | 1.08 (0.35) |