Fig. 1

Neuroprotection of GPR30 against ischemic stroke. a Representative photographs of brain slices showing the infarct volume assessed 24 h after reperfusion in OVX mice after MCAO/R injury. b Infarction volume as a percentage of the sham value. The data are expressed as the mean ± SD and analyzed by one-way ANOVA with Tukey’s post-test. **p < 0.01, ***p < 0.001 compared with the vehicle group. n = 6 per group. c Neurological deficit scores evaluated 24 h after reperfusion in OVX mice after MCAO/R injury. The data are expressed as the median and were analyzed by the Mann-Whitney U test. ^###p < 0.001 compared with the sham group. ***p < 0.001 compared with the vehicle group. n = 10 per group. OVX mice ovariectomized mice, MCAO/R middle cerebral artery occlusion/reperfusion