Fig. 1

Transcriptional changes in aging Tg2576 and TgCRND8 brain. a Student’s t test p value distributions for gene expression differences between WT and Tg2576 (left plot) or TgCRND8 (right plot) at different ages. Gray line indicates expected false discovery rate (FDR) given multiple test comparisons. b Heatmap showing log₁₀ ratio values from each sample (y-axis) for each gene (x-axis) with t test p < 0.001 between Tg2576 (green) and TgCRND8 (blue) versus WT littermate controls at one or more ages. Samples are ordered manually by genotype as indicated. Genes are ordered by test and agglomerative clustering. c Heatmaps showing log₁₀ ratio values from each sample (y-axis) for each gene (x-axis) within the indicated gene sets. Samples are ordered manually by genotype as indicated. Genes are ordered by agglomerative clustering within each set. d Signature scores (average of gene values in C ± standard deviation) for the indicated gene sets over age in Tg2576 (green) and WT littermate control (gray) as well as TgCRND8 (blue) and WT littermate controls (black)