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Fig. 2 | Journal of Neuroinflammation

Fig. 2

From: Cell permeable HMGB1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke

Fig. 2

HBHP alleviated tPA-induced hemorrhage in stroke rats with 4.5 h MCAO. a, b Representative brain coronal sections showing hemorrhage and hemispheric enlargement in 2 h MCAO rats plus 22 h reperfusion with different treatments. c, d Brain slices showing hemorrhage and brain hemoglobin contents in 4.5 h MCAO rats at 24 h after ischemia onset. e, f Brain slices and hemoglobin contents in 4.5 h MCAO rats at 8 h after ischemia onset. Hemoglobin content was quantified and presented as bar graph. NS: not significant; *P < 0.05, **P < 0.01; n = 5–8. Data were shown as mean ± SD

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