Fig. 6

NLRP3 knockdown in BV2 cells could inhibit the apoptosis of PC12 cells in the transwell co-cultures after OGD/R. a, b The rate of apoptotic PC12 cells among the different groups, as measured by flow cytometry. OGD/R treatment in isolated cultures or transwell co-cultures was conducted at 24 h after siRNA transfection. *p < 0.05, **p < 0.01. OGD/R: oxygen-glucose deprivation/reoxygenation. The OGD continued for 4 h, followed by reoxygenation